The enzyme citramalyl-CoA lyase (EC 4.1.3.25) catalyzes the chemical reaction

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is (3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming). Other names in common use include citramalyl coenzyme A lyase, (+)-CMA-CoA lyase, and (3S)-citramalyl-CoA pyruvate-lyase. This enzyme participates in pyruvate metabolism and c5-branched dibasic acid metabolism.

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